X-ray powder diffraction analysis of imipenem monohydrate

An experimental X-ray powder diffraction pattern was produced and analyzed for imipenem monohydrate, an antimicrobial pharmaceutical agent. Although there are no experimental powder patterns in the ICDD PDF-4/Organics Database, there is one powder pattern calculated with single-crystal X-ray diffrac...

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Bibliographic Details
Published inPowder diffraction Vol. 27; no. 1; pp. 20 - 24
Main Authors Needham, F., Crowder, C. E., Reid, J. W., Fawcett, T. G., Faber, J.
Format Journal Article
LanguageEnglish
Published New York, USA Cambridge University Press 01.03.2012
Subjects
Crystals
Diffraction
Diffraction patterns
Mathematical analysis
Single crystals
Unit cell
X-rays
hydrogen bonding
C12H17N3O4S
β-lactam
imipenem
X-ray powder diffraction
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Summary:An experimental X-ray powder diffraction pattern was produced and analyzed for imipenem monohydrate, an antimicrobial pharmaceutical agent. Although there are no experimental powder patterns in the ICDD PDF-4/Organics Database, there is one powder pattern calculated with single-crystal X-ray diffraction data from the Cambridge Structural Database. Here, we report the refined experimental powder diffraction data for imipenem monohydrate. These data for imipenem monohydrate are consistent with an orthorhombic crystal system having reduced unit-cell parameters of a = 8.2534(3) Å, b = 11.1293(4) Å, and c = 15.4609(6) Å. The resulting unit-cell volume, 1420.15(15) Å3, indicates four formula units per unit cell. Observed peaks are consistent with the P212121 space group.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0885-7156
1945-7413
DOI:10.1017/S0885715612000048