Investigation of the Ability to Detect Electrolyte Disorder Using PET with Positron Annihilation Lifetime Spectroscopy

Various concentrations (8-300 mmol/L) of NaCl, KCl, and NaCl + KCl aqueous solutions were investigated using positron annihilation lifetime spectroscopy (PALS). A strong dependence of the -Ps intensity as a function of the solution concentration was demonstrated. On this basis, the mean positron lif...

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Published inThe journal of physical chemistry. B Vol. 127; no. 46; pp. 9887 - 9890
Main Authors Zaleski, Radosław, Kotowicz, Olga, Górska, Agnieszka, Zaleski, Kamil, Zgardzińska, Bożena
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 23.11.2023
Subjects
Electrolytes
Electrons
Positron-Emission Tomography
Sodium Chloride
Spectrum Analysis - methods
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Summary:Various concentrations (8-300 mmol/L) of NaCl, KCl, and NaCl + KCl aqueous solutions were investigated using positron annihilation lifetime spectroscopy (PALS). A strong dependence of the -Ps intensity as a function of the solution concentration was demonstrated. On this basis, the mean positron lifetime and the sum of counts in a selected time interval were proposed as reliable parameters for detecting disturbances in the ion balance of living organisms. The use of these parameters for differentiating healthy and cancerous tissues allows for the development of auxiliary diagnostic methods in a new generation of PET scanners equipped with a PALS detection module.
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ISSN:1520-6106
1520-5207
1520-5207
DOI:10.1021/acs.jpcb.3c04208