Segmentation of Arm Ultrasound Images in Breast Cancer-Related Lymphedema: A Database and Deep Learning Algorithm

• Published in: IEEE transactions on biomedical engineering Vol. 70; no. 9; pp. 1 - 12
• Main Authors: Goudarzi, Sobhan, Whyte, Jesse, Boily, Mathieu, Towers, Anna, Kilgour, Robert D., Rivaz, Hassan
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.09.2023; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Algorithms; Artificial neural networks; Biomarkers; Breast cancer; Cancer therapies; Damage prevention; Datasets; Deep learning; Diagnosis; Drainage systems; Image processing; Image segmentation; Imaging; Lymph nodes; Lymphatic drainage; Lymphedema; Machine learning; Masks; Mechanical properties; Medical imaging; Medical ultrasound imaging; Monitoring; Neural networks; Radio frequency; Segmentation; Skin; Therapeutic applications; Three-dimensional displays; Ultrasonic imaging; Ultrasound
• ISSN: 0018-9294; 1558-2531; 1558-2531
• DOI: 10.1109/TBME.2023.3253646

Objective: Breast cancer treatment often causes the removal of or damage to lymph nodes of the patient's lymphatic drainage system. This side effect is the origin of Breast Cancer-Related Lymphedema (BCRL), referring to a noticeable increase in excess arm volume. Ultrasound imaging is a preferred modality for the diagnosis and progression monitoring of BCRL because of its low cost, safety, and portability. As the affected and unaffected arms have similar appearances in B-mode ultrasound images, the thickness of the skin, subcutaneous fat, and muscle have been shown to be important biomarkers for this task. The segmentation masks are also helpful in monitoring the longitudinal changes in morphology and mechanical properties of each tissue layer. Methods: For the first time, a publicly available ultrasound dataset containing the Radio-Frequency (RF) data of 39 subjects as well as manual segmentation masks by two experts, are provided. Inter- and intra-observer reproducibility studies performed on the segmentation maps show a high Dice Score Coefficient (DSC) of <inline-formula><tex-math notation="LaTeX">0.94\pm 0.08</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">0.92\pm 0.06</tex-math></inline-formula>, respectively. Gated Shape Convolutional Neural Network (GSCNN) is modified for precise automatic segmentation of tissue layers, and its generalization performance is improved by the CutMix augmentation strategy. Results: We got an average DSC of <inline-formula><tex-math notation="LaTeX">0.87\pm 0.11</tex-math></inline-formula> on the test set, which confirms the high performance of the method. Conclusion: Automatic segmentation methods can pave the way for convenient and accessible staging of BCRL, and our dataset can facilitate development and validation of those methods. Significance: Timely diagnosis and treatment of BCRL are of crucial importance to prevent irreversible damage.