Electrosprayed Folic Acid-Conjugated Ursolic Acid Nanoparticles for Tumor Therapy

We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evalu...

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Bibliographic Details
Published inMacromolecular research Vol. 26; no. 7; pp. 573 - 576
Main Authors Ahn, Guk Young, Paik, Dong-Hyun, Jeong, Ki-Young, Baek, Seung-Woon, Kang, Rae-Hyoung, Lee, Eun Seong, Choi, Sung-Wook
Format Journal Article
LanguageEnglish
Published Seoul The Polymer Society of Korea 01.07.2018
Springer Nature B.V
한국고분자학회
Subjects
Acids
Cancer
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Communication
Complex Fluids and Microfluidics
Cytotoxicity
Electrospraying
Fluorescence
Folic acid
Nanochemistry
Nanoparticles
Nanotechnology
Physical Chemistry
Polymer Sciences
Soft and Granular Matter
Toxicity
고분자공학
electrospraying
folic acid
tumor therapy
ursolic acid
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Summary:We describe a simple method for the fabrication of folic acid-conjugated ursolic acid (FA-UA) nanoparticles using electrospraying. The FA-UA nanoparticles had an average size of 90.6 nm and exhibited greater cellular uptake compared with pristine UA and electrosprayed UA nanoparticles. We also evaluated the cytotoxicity of pristine UA, electrosprayed UA nanoparticles, and FA-UA nanoparticles over time and under different UA concentrations. In vitro , the FA-UA nanoparticles showed significantly higher cytotoxicity in KB cells compared with pristine UA and electrosprayed UA nanoparticles. These results were corroborated by LIVE/DEAD staining and fluorescence imaging of cancer cells. Thus, FA-UA nanoparticles can potentially be used for targeting drugs in cancer therapies.
ISSN:1598-5032
2092-7673
DOI:10.1007/s13233-018-6089-x