Biomagnetic signals recorded during transcranial magnetic stimulation (TMS)-evoked peripheral muscular activity

• Published in: Biomedizinische Technik Vol. 67; no. 5; pp. 333 - 344
• Main Authors: Iwata, Geoffrey Z., Hu, Yinan, Wickenbrock, Arne, Sander, Tilmann, Muthuraman, Muthuraman, Chirumamilla, Venkata Chaitanya, Groppa, Sergiu, Liu, Qishan, Budker, Dmitry
• Format: Journal Article
• Language: English; German
• Published: Berlin De Gruyter 26.10.2022; Walter de Gruyter GmbH
• Subjects: biomagnetic signals; Electric contacts; Electromyography; Human motion; Magnetic fields; Magnetic measurement; Magnetic recording; Magnetometers; magnetomyograms; Muscles; optically pumped magnetometers; Transcranial magnetic stimulation
• ISSN: 0013-5585; 1862-278X
• DOI: 10.1515/bmt-2021-0019

Transcranial magnetic stimulation (TMS) has widespread clinical applications from diagnosis to treatment. We combined TMS with non-contact magnetic detection of TMS-evoked muscle activity in peripheral limbs to explore a new diagnostic modality that enhances the utility of TMS as a clinical tool by leveraging technological advances in magnetometry. We recorded measurements in a regular hospital room using an array of optically pumped magnetometers (OPMs) inside a portable shield that encloses only the forearm and hand of the subject. We present magnetomyograms (MMG)s of TMS-evoked movement in a human hand, together with a simultaneous surface electromyograph (EMG) data. The biomagnetic signals recorded in the MMG provides detailed spatial and temporal information that is complementary to that of the electric signal channels. Moreover, we identify features in the magnetic recording beyond that of the EMG. This system demonstrates the value of biomagnetic signals in TMS-based clinical approaches and widens its availability and practical potential.