Correlation analysis of secondary metabolites and disease resistance activity of different varieties of Congou black tea based on LC-MS/MS and TCMSP

• Published in: Food Chemistry: X Vol. 23; p. 101331
• Main Authors: Liu, Zhongying, Ran, Qiansong, Luo, Jinlong, Shen, Qiang, Zhang, Tuo, Fang, Shimao, Pan, Ke, Long, Lin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 30.10.2024; Elsevier
• Subjects: Congou black tea; Correlation; Disease-resistance activity; Metabolomics; Secondary metabolites; Metabolomics; Disease-resistance activity; Secondary metabolites; Correlation; Congou black tea
• ISSN: 2590-1575; 2590-1575
• DOI: 10.1016/j.fochx.2024.101331

To investigate the correlation between the difference of secondary metabolites and the disease-resistance activity of different varieties of Congou black tea. Among a total of 657 secondary metabolites identified, 183 metabolites had anti-disease activity, 113 were key active ingredients in traditional Chinese medicine (TCM), 73.22% had multiple anti-disease activities, and all were mainly flavonoids and phenolic acids. The main enriched metabolic pathways were phenylpropanoid biosynthesis, biosynthesis of secondary metabolites, flavonoid biosynthesis, and metabolic pathways. Flavonoid and phenolic acid secondary metabolites were more correlated with anti-disease activity and key active TCM ingredients. Conclusion: The types of JGY and Q601 Congou black tea of the relative contents show large differences in secondary metabolites. Flavonoid and phenolic acid secondary metabolites were identified as the primary factors contributing to the variation in secondary metabolites among different varieties of Congou black tea. These compounds also exhibited a stronger correlation with disease resistance activity. •657 secondary metabolites has been identified.•183 metabolites have anti-disease activity.•The secondary metabolites between JGY and Q601 were greater differences.•The main enriched metabolic pathways were phenylpropanoid biosynthesis.•Flavonoid and phenolic acid were more correlated with antidisease activity.