Serum zinc levels and Alzheimer's disease

Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum wa...

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Bibliographic Details
Published inBiological trace element research Vol. 75; no. 1-3; pp. 79 - 85
Main Authors Rulon, L L, Robertson, J D, Lovell, M A, Deibel, M A, Ehmann, W D, Markesber, W R
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 2000
Subjects
Aged
Alzheimer Disease - metabolism
Alzheimer's disease
Atomic absorption spectroscopy
Brain
Brain Chemistry - physiology
Female
Humans
Male
Neutrons
Spectral analysis
Spectrometry
Spectrophotometry, Atomic
Zinc
Zinc - blood
Zinc - metabolism
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Summary:Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum was observed in AD subjects (136.4+/-66.8 microg/dL) compared with age-matched control subjects (71.1+/-35.0 microg/dL). No significant differences were observed between AD and control zinc concentrations in the amygdala, hippocampus, cerebellum, and superior and middle temporal gryi.
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ISSN:0163-4984
0163-4984
1559-0720
DOI:10.1385/BTER:75:1-3:79