Hypoalbuminemia in colorectal cancer prognosis：Nutritional marker or inflammatory surrogate

Albumin is the single most abundant protein in thehuman serum. Its roles in physiology and pathologyare diverse. Serum albumin levels have been classicallythought to reflect the nutritional status of patients. Thisconcept has been challenged in the last two decadesas multiple factors, such as inflam...

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Bibliographic Details
Published inWorld journal of gastrointestinal surgery Vol. 7; no. 12; pp. 370 - 377
Main Author Nazha, Bassel
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 27.12.2015
Subjects
Albumin
Albumin-to-globulin
Cancer
Colorectalcancer
Glasgow
Hypoalbuminemia
inflammatory
Minireviews
prognosticscore
ratio
response
survival;Systemic
Glasgow prognostic score
Hypoalbuminemia
Albumin-to-globulin ratio
Cancer survival
Colorectal cancer
Albumin
Systemic inflammatory response
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Summary:Albumin is the single most abundant protein in thehuman serum. Its roles in physiology and pathologyare diverse. Serum albumin levels have been classicallythought to reflect the nutritional status of patients. Thisconcept has been challenged in the last two decadesas multiple factors, such as inflammation, appearedto affect albumin levels independent of nutrition. Ingeneral,cancer patients have a high prevalence ofhypoalbuminemia. As such, the role of hypoalbuminemiain patients with colorectal cancer has receivedsignificant interest. We reviewed the English literatureon the prognostic value of pretreatment albumin levelsin colorectal cancer. We also consolidated the evidencethat led to the current understanding of hypoalbuminemiaas an inflammatory marker rather than as anutritional one among patients with colorectal cancer.
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Author contributions: All authors contributed to the literature review and manuscript writing; the final version of the manuscript was approved by all authors.
Correspondence to: Bassel Nazha, MD, MPH, Resident Physician, Department of Medicine, North Shore-LIJ Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, United States. bnazha@nshs.edu
ISSN:1948-9366
1948-9366
DOI:10.4240/wjgs.v7.i12.370