Targeting adipose tissue in the treatment of obesity-associated diabetes

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse...

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Bibliographic Details
Published inNature reviews. Drug discovery Vol. 15; no. 9; pp. 639 - 660
Main Authors Kusminski, Christine M, Bickel, Perry E, Scherer, Philipp E
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2016
Subjects
Adipose Tissue - drug effects
Adipose Tissue - pathology
Adipose Tissue - physiopathology
Animals
Body fat
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Homeostasis - drug effects
Humans
Insulin Resistance
Obesity - drug therapy
Obesity - pathology
Obesity - physiopathology
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Summary:Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.
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ISSN:1474-1776
1474-1784
DOI:10.1038/nrd.2016.75