Mulberry Leaf Extract Improves Postprandial Glucose Response in Prediabetic Subjects: A Randomized, Double-Blind Placebo-Controlled Trial

• Published in: Journal of medicinal food Vol. 18; no. 3; pp. 306 - 313
• Main Authors: Kim, Ji Yeon, Ok, Hyang Mok, Kim, Joohee, Park, Seok Won, Kwon, Sung Won, Kwon, Oran
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.03.2015
• Subjects: Area Under Curve; Biological Assay; Blood Glucose - metabolism; c-peptide; C-Peptide - metabolism; Dietary Supplements; Double-Blind Method; Fasting; Female; glucose; Glucose Intolerance - blood; Glucose Intolerance - drug therapy; glycemic control; glycemic effect; Humans; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Insulin - blood; leaf extracts; leaves; Male; Middle Aged; Morus; mulberries; Phytotherapy; placebos; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Leaves; Postprandial Period; Prediabetic State - blood; Prediabetic State - drug therapy; 1-deoxynojirimycin; mulberry leaf aqueous extract; postprandial glycemic control
• ISSN: 1557-7600; 1557-7600
• DOI: 10.1089/jmf.2014.3160

This study was a randomized, double-blind placebo-controlled trial to assess the efficacy of 4 weeks of mulberry leaf aqueous extract (MLAE) supplementation (5 g/day) for postprandial glycemic control in 36 subjects with impaired fasting glucose (IFG) tolerance. Postprandial responses in the glucose, insulin, and C-peptide levels were measured after a carbohydrate load both at baseline and after 4 weeks of MLAE supplementation. The postprandial glycemic response was attenuated in the MLAE group after the treatment period, particularly 30 and 60 min after loading (P=.003 and 0.0325 for glucose, P=.0005 and .0350 for insulin, and P=.0151 and .0864 for C-peptide). Additionally, the incremental area under the curve for insulin was significantly lower in the MLAE group than in the placebo group (P=.0207). Four weeks of MLAE supplementation improved postprandial glycemic control in individuals with IFG tolerance.