Relative Comparison of Catalytic Characteristics of Human Foamy Virus and HIV-1 Integrases

Due to their ability to integrate into the host cell's genome, retroviruses represent an optimal basis for the creation of gene therapy vectors. The integration reaction is carried out by a viral enzyme integrase: thus, a detailed research of this enzyme is required. In this work, the catalytic...

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Published inActanaturae Vol. 1; no. 2; pp. 78 - 80
Main Authors Knyazhanskaya, E S, Smolov, M A, Kondrashina, O V, Gottikh, M B
Format Journal Article
LanguageEnglish
Published Russia (Federation) A.I. Gordeyev 01.07.2009
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Summary:Due to their ability to integrate into the host cell's genome, retroviruses represent an optimal basis for the creation of gene therapy vectors. The integration reaction is carried out by a viral enzyme integrase: thus, a detailed research of this enzyme is required. In this work, the catalytic properties of human foamy virus integrase were studied. This virus belongs to the Retroviridae family. The dissociation constant was determined, together with the kinetics of integrase catalytic activity. The data obtained were compared to those for the human immunodeficiency virus integrase and a considerable similarity in the activity of the two enzymes was observed.
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gottikh@libro.belozersky.msu.ru
ISSN:2075-8251
DOI:10.32607/20758251-2009-1-2-78-80