Biclonal gammopathy of undetermined significance in a patient with systemic lupus erythematosus and antiphospholipid syndrome

The case of a patient suffering from systemic lupus erythematosus with associated antiphospholipid antibody syndrome is described. In this patient, on protein electrophoresis, two monoclonal immunoglobulin G λ and k peaks were seen, defining a condition of biclonal gammopathy of undetermined signifi...

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Bibliographic Details
Published inReumatismo Vol. 73; no. 4
Main Authors Bruzzese, V, Scolieri, P, Pepe, J
Format Journal Article
LanguageEnglish
Published Italy PAGEPress Publications 07.02.2022
Subjects
Amyloidosis
Anemia
Antibodies
Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - diagnosis
APS
Biclonal gammopathy
Bone marrow
Cancer
Conflicts of interest
Humans
Immunoglobulin G
infection
Internal medicine
Leukemia
Light
Lupus
Lupus Erythematosus, Systemic - complications
Lymphoma
Medical imaging
Neoplasms
neoplastic disease
Proteins
Rheumatic diseases
Rheumatology
SLE
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Summary:The case of a patient suffering from systemic lupus erythematosus with associated antiphospholipid antibody syndrome is described. In this patient, on protein electrophoresis, two monoclonal immunoglobulin G λ and k peaks were seen, defining a condition of biclonal gammopathy of undetermined significance (BGUS). This condition is extremely rare, especially in chronic inflammatory rheumatic diseases. The criteria of a BGUS are defined. We also underline how this condition can be the expression of a concomitant unrecognized cancer, a possible amyloidosis or an infectious process.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0048-7449
2240-2683
DOI:10.4081/reumatismo.2021.1431