The relation between endothelin-1 levels and myocardial injury in chronic ischemic heart failure

• Published in: Heart and vessels Vol. 20; no. 3; pp. 95 - 99
• Main Authors: Yazici, Mustafa, Demircan, Sabri, Durna, Kenan, Sahin, Mahmut
• Format: Journal Article
• Language: English
• Published: Japan Springer Nature B.V 01.05.2005
• Subjects: Analysis of Variance; Case-Control Studies; Chi-Square Distribution; Chronic Disease; Comparative analysis; Echocardiography; Endothelin-1 - blood; Female; Heart failure; Humans; Male; Middle Aged; Myocardial Ischemia - blood; Myocardial Ischemia - diagnostic imaging; Peptides; Severity of Illness Index; Troponin I - blood; Ultrasonic imaging
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-004-0812-6

We evaluated whether there was any relation between myocardial injury and endothelin-1 (ET-1) levels, which has been suggested as a contributor to the progression of ischemic heart failure. One hundred and twenty-one patients with chronic ischemic heart failure and 37 healthy individuals were included in the study. Cardiac troponin-I (cTn-I) and ET-1 levels of all subjects were measured on admission. Echocardiographic evaluations were also performed. The positivity of cTn-I increased significantly as the severity changed from New York Heart Association (NHYA) Class I to IV (P < 0.01). This was also true for quantitative cTn-I levels (P < 0.05). The ET-1 levels of patients were higher than controls on admission (P < 0.001). The ET-1 levels increased significantly upon the progression from NHYA Class I to IV (P < 0.001). Moreover, patients with cTn-I positivity had higher ET-1 levels (P < 0.05) and a lower ejection fraction (P < 0.001). A negative correlation was found between ejection fraction and the ET-1 levels (r = -0.312, P = 0.019). In patients with cTn-I positivity, the cTn-I levels showed a positive correlation with the ET-1 levels (r = 0.328, P = 0.014) and a negative correlation with ejection fraction (r = -0.671, P < 0.001). In chronic ischemic heart failure, an increase in ET-1 may exert an influence on the progression of cardiac failure by leading to myocardial injury which may be demonstrated by higher cTn-I levels.