One Pot Synthesis of Monoalkylated and Mixed, Dialkylated Meldrum's Acid Derivatives

A simple one pot method, involving sequential Knoevenagel condensation of Meldrum's acid with aromatic aldehydes, conjugate reduction of ylidene Meldrum's acid using sodium borohydride followed by alkylation, to prepare mixed dialkylated derivatives of Meldrum's acid is described.

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Bibliographic Details
Published inSynthetic communications Vol. 34; no. 1; pp. 25 - 32
Main Authors Desai, Uday V., Pore, D. M., Mane, R. B., Solabannavar, S. B., Wadgaonkar, P. P.
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 31.12.2004
Taylor & Francis
Subjects
Aldehyde
Chemistry
Chemistry, Organic
Knoevenagel condensation
Meldrum's acid
Physical Sciences
Science & Technology
KETONES
ISOPROPYLIDENE MALONATE
CLEAN SYNTHESIS
REDUCTION
Knoevenagel condensation
ALKYLATION
METHYLENEKETENES
aldehyde
CONDENSATION
Meldrum's acid
METHYLENECARBENES
WATER
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Summary:A simple one pot method, involving sequential Knoevenagel condensation of Meldrum's acid with aromatic aldehydes, conjugate reduction of ylidene Meldrum's acid using sodium borohydride followed by alkylation, to prepare mixed dialkylated derivatives of Meldrum's acid is described.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120027234