Is there any relationship between LGALS3 gene variations and histopathological criteria in laryngeal squamous cell carcinoma (LSCC)?

• Published in: Turkish Journal of Biochemistry Vol. 46; no. 6; pp. 703 - 708
• Main Authors: Horozoglu, Cem, Demirkol, Seyda, Verim, Aysegul, Sonmez, Dilara, Sürmen, Saime, Kucukhuseyin, Ozlem, Zeybek, Umit, Yaylim, Ilhan
• Format: Journal Article
• Language: English
• Published: De Gruyter 30.12.2021
• Subjects: galectin-3; Galektin-3; LGALS3; LSCC; rs4644; rs4652
• ISSN: 0250-4685; 1303-829X
• DOI: 10.1515/tjb-2020-0177

Abstract Objectives Genetic variations of LGALS3 (Galectin-3) were found to be associated with treatment resistance, mortality, recurrence, high tumor volume and multiple tumor involvement in solid organ cancers. The modulators of extracellular matrix (ECM), which is a dynamic factor in the larynx tissue with high biomechanical and regenerating ability, can play an important role. We aimed to investigate the relationship between the genetic variants of LGALS3, one of these modulators, with Laryngeal Squamous Cell Carcinoma (LSCC). Methods LGALS3 gene variations were genotyped by PCR-RFLP method using genomic DNA samples obtained from peripheral blood samples of 74 patients diagnosed with LSCC and 94 healthy controls. Results The C allele carriage for the Rs4652 genetic variant was found to be higher (p=0.017) in patients with LSCC. Statistical relationships were found between homozygous genotypes of this variant (CC/AA) with advanced tumor stage (p=0.017) and presence of reflux (p=0.036). CC genotype for rs4644 was found to be higher in cases with positive family history (p=0.036). Conclusions Our findings of LGALS3 gene variants, which are also found to be associated with other solid cancers, suggest that they may play a role in LSCC pathophysiology similarly.