Immunotherapeutic implications on targeting the cytokines produced in rhinovirus-induced immunoreactions

• Published in: Frontiers in allergy Vol. 5; p. 1427762
• Main Authors: Sang, Le, Gong, Xia, Huang, Yunlei, Zhang, Linling, Sun, Jian
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.05.2024
• Subjects: Allergy; cytokines; immunoreactions; rhinovirus; rhinovirus-related diseases; therapies for rhinovirus infection; immunoreactions; therapies for rhinovirus infection; cytokines; rhinovirus; rhinovirus-related diseases
• ISSN: 2673-6101; 2673-6101
• DOI: 10.3389/falgy.2024.1427762

Rhinovirus is a widespread virus associated with several respiratory diseases, especially asthma exacerbation. Currently, there are no accurate therapies for rhinovirus. Encouragingly, it is found that during rhinovirus-induced immunoreactions the levels of certain cytokines in patients' serum will alter. These cytokines may have pivotal pro-inflammatory or anti-inflammatory effects via their specific mechanisms. Thus far, studies have shown that inhibitions of cytokines such as IL-1, IL-4, IL-5, IL-6, IL-13, IL-18, IL-25, and IL-33 may attenuate rhinovirus-induced immunoreactions, thereby relieving rhinovirus infection. Furthermore, such therapeutics for rhinovirus infection can be applied to viruses of other species, with certain practicability.