Glycemic status, lipid profile and proteinuria in diabetic nephropathy

• Published in: Journal of Nepal Medical Association Vol. 49; no. 178; pp. 143 - 146
• Main Authors: Jha, P, Das, B K L, Shrestha, S, Majhi, S, Chandra, L, Sharma, S, Baral, N
• Format: Journal Article
• Language: English
• Published: Nepal Nepal Medical Association 01.04.2010
• Subjects: Adult; Aged; Albuminuria - complications; Blood Glucose - metabolism; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Creatinine - blood; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - urine; Diabetic Nephropathies - blood; Diabetic Nephropathies - etiology; Diabetic Nephropathies - urine; Female; Glycated Hemoglobin A - metabolism; Humans; Lipids - blood; Male; Middle Aged; Triglycerides - blood; Urea - blood
• ISSN: 0028-2715; 1815-672X
• DOI: 10.31729/jnma.115

Diabetic nephropathy is one of the major complications of Diabetes Mellitus characterized by persistent albuminuria, elevated arterial blood pressure, a relentless decline in glomerular filtration rate (GFR) and a high risk of cardiovascular morbidity and mortality. In this study, urinary micro-albumin estimation was done in 177 diabetic patients. This study aims to ascertain association of glycemic status, lipid profile and proteinuria in Type 2 Diabetes Mellitus with nephropathy. Among 177 patients, 26 had frank proteinuria, 79 had micro-albuminuria and 72 were without proteinuria. Increased frequency of proteinuria was seen in male than female. Micro-albuminuria and frank proteinuria was seen more in older age group. The multiple comparisons showed the significantly increased levels of urea, creatinine, fasting blood glucose in micro-albuminuria and overt proteinuria patients in comparison to without proteinuria. Glycated hemoglobin level was increased with the increasing age group particularly in overt proteinuric patients. The glycemic control, monitoring of lipid profile and early urinary protein estimation with better management may delay diabetic nephropathy or its further complications in diabetes mellitus.