Gut microbiota and female health

The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as...

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Published inWorld journal of gastroenterology : WJG Vol. 30; no. 12; pp. 1655 - 1662
Main Authors Wang, Meng-Yao, Sang, Li-Xuan, Sun, Si-Yu
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 28.03.2024
Subjects
Breast Neoplasms
Dysbiosis
Endometriosis
Estrogens
Female
Gastrointestinal Microbiome
Humans
Gut microbiota
Polycystic ovarian syndrome
Endometriosis
Estrogen
Female health
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Summary:The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore the critical role of gut microbial homeostasis in female health; with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer, and ovarian cancer Despite this, there has been limited discussion on the underlying mechanisms. This editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women, namely, the immune system, the gut microbiota-estrogen axis, and the metabolite pathway. We focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics, prebiotics supplementation, and fecal microbiota transplantation (FMT). Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine, with FMT emerging as a promising intervention.
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Supported by Science and Technology Plan of Liaoning Province, No. 2022JH2/101500063.
Author contributions: Sang LX and Sun SY designed the editorial; Wang MY wrote the draft; Sang LX revised the article for important intellectual content; Sun SY approved the final version, and each author contributed important intellectual content during manuscript drafting and revision.
Corresponding author: Si-Yu Sun, MD, PhD, Chief Doctor, Director, Professor, Department of Gastroenterology, Endoscopic Center, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. sun-siyu@163.com
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v30.i12.1655