CT Color Mapping of the Arterial Enhancement Fraction of VX2 Carcinoma Implanted in Rabbit Liver: Comparison With Perfusion CT

• Published in: American journal of roentgenology (1976) Vol. 196; no. 1; pp. 102 - 108
• Main Authors: KYUNG WON KIM, JEONG MIN LEE, JAE HYUNG KIM, KLOTZ, Ernst, KIM, Hyo-Cheol, JOON KOO HAN, BYUNG IHN CHOI
• Format: Journal Article
• Language: English
• Published: Reston, VA American Roentgen Ray Society 2011
• Subjects: Animals; Biological and medical sciences; Contrast Media; Gastroenterology. Liver. Pancreas. Abdomen; Immunohistochemistry; Linear Models; Liver Neoplasms - blood supply; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Rabbits; Software; Statistics, Nonparametric; Tomography, X-Ray Computed - methods; Tumors; Cartography; Carcinoma; Radiodiagnosis; liver; Rabbit; Hepatic disease; Malignant tumor; hepatic perfusion index; Lagomorpha; perfusion CT; Liver cancer; Vertebrata; Mammalia; Perfusion; Animal; Established cell line; Medical imagery; Digestive diseases; Computerized axial tomography; Technique; arterial enhancement fraction; Comparative study; Cancer
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/AJR.09.3971

The purpose of this study was to compare the arterial enhancement fraction (AEF) calculated at multiphasic liver CT with the hepatic perfusion index (HPI) measured with cine mode perfusion CT. Cine mode perfusion CT was performed after VX2 tumor implantation in the livers of 10 rabbits. HPI and its color map were obtained with a computer application. With raw data from cine mode perfusion CT, images were extracted in the unenhanced, arterial, and portal venous phases to simulate multiphasic liver CT. On the basis of simulated multiphasic CT images, the AEF color map was obtained with prototype software. HPI and AEF were compared for the same regions of interest in the liver parenchyma, whole liver tumor, and viable tumor portion. In the liver parenchyma, the mean HPI was 23.3% ± 2.6% (SD) and the AEF 24.4% ± 2.8%; in whole liver tumor, 73.4% ± 9.5% and 78.4% ± 10.5%; and in the viable tumor portion, 78.0% ± 7.7% and 78.3% ± 7.5%. The differences were not statistically significant (p > 0.05, Wilcoxon's signed rank test). Measurement agreement between the two parameters was moderate (Bland-Altman 95% limits of agreement, -14.9% and 19.2%), but there was a strong positive correlation between AEF and HPI (within-subject r = 0.91, p < 0.001). Functional maps of HPI and AEF correlated with the histologic findings. AEF calculated from simulated multiphasic liver CT images correlates strongly with HPI obtained at cine mode perfusion CT. Further study of the AEF is warranted to explore its value in providing hepatic perfusion information without additional radiation exposure.