MDCT for Suspected Acute Appendicitis in Adults: Impact of Oral and IV Contrast Media at Standard-Dose and Simulated Low-Dose Techniques

• Published in: American journal of roentgenology (1976) Vol. 193; no. 5; pp. 1272 - 1281
• Main Authors: Keyzer, Caroline, Cullus, Pierre, Tack, Denis, De Maertelaer, Viviane, Bohy, Pascale, Gevenois, Pierre Alain
• Format: Journal Article
• Language: English
• Published: Reston, VA Am Roentgen Ray Soc 01.11.2009; American Roentgen Ray Society
• Subjects: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Appendicitis - diagnostic imaging; Biological and medical sciences; Contrast Media - administration & dosage; Factor Analysis, Statistical; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Injections, Intravenous; Investigative techniques, diagnostic techniques (general aspects); Iothalamic Acid - administration & dosage; Iothalamic Acid - analogs & derivatives; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Prospective Studies; Radiographic Image Interpretation, Computer-Assisted; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tomography, Spiral Computed - methods; Human; Nuclear medicine; Appendicitis; Acute; Low dose; Oral administration; Standards; Multidetector scanner; Radiology; Digestive diseases; Intestinal disease; Adult; Technique; Contrast media
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/AJR.08.1959

The objective of this study was to prospectively investigate the influence of oral, IV, and oral and IV contrast media on the information provided by MDCT at standard and simulated low radiation doses in adults suspected of having acute appendicitis. One hundred thirty-one consecutive patients (80 women, 51 men; age range, 18-87 years; mean age, 37 years) suspected of having appendicitis were randomly assigned to either ingest or not ingest iodinated contrast material. Thereafter, all patients underwent IV unenhanced and enhanced abdominopelvic MDCT with a 4 x 2.5 mm collimation at 120 kVp and 100 mAs(eff). Dose reduction corresponding to 30 mAs(eff) was simulated. Two radiologists independently read scans during separate sessions, assessed appendix visualization, and proposed a diagnosis (i.e., appendicitis or an alternative diagnosis). The final diagnosis was based on either surgical findings or clinical follow-up. Data were analyzed by factorial analysis of multiple correspondences followed by an ascending hierarchic classification method. Factorial analysis and ascending hierarchic classification revealed that, in terms of diagnostic correctness, reader influence predominated over the influence of IV and oral contrast media use and radiation dose but that correctness was also influenced by the patient's sex (p = 0.048) and was lower in cases of alternative diseases (p < 0.001). Visualization of the appendix depended predominantly on the reader rather than on the use of IV, oral, or oral and IV contrast agents or on radiation dose. Diagnostic correctness is much more influenced by the reader than by the use of contrast medium (oral, IV, or both) or of simulated low-radiation-dose technique.