Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-β ?

Interferon-beta1b treatment in relapsing-remitting multiple sclerosis can frequently induce systemic side effects such as flu-like symptoms with fever. In vitro stimulation of peripheral blood leukocytes with interferon-beta1b before the beginning of therapy shows that patients who develop fever gen...

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Bibliographic Details
Published inJournal of neurology Vol. 247; no. 4; pp. 259 - 262
Main Authors MONTALBAN, X, DURAN, I, RIO, J, SAEZ-TORRES, I, TINTORE, M, MARTINEZ-CACERES, E. M
Format Journal Article
LanguageEnglish
Published Berlin Springer 01.04.2000
Subjects
Adult
Biological and medical sciences
Cohort Studies
Female
Flow Cytometry
Humans
In Vitro Techniques
Influenza, Human - complications
Interferon-beta - therapeutic use
Interleukin-10 - blood
Interleukin-6 - blood
Male
Medical sciences
Multiple Sclerosis - complications
Multiple Sclerosis - drug therapy
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Predictive Value of Tests
Retrospective Studies
Tumor Necrosis Factor-alpha - metabolism
Human
Nervous system diseases
Multiple sclerosis
Cytokine
Exploration
Fever
Inflammatory disease
Infection
Interleukin 6
Chemotherapy
Treatment
Viral disease
Influenza
Central nervous system disease
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Summary:Interferon-beta1b treatment in relapsing-remitting multiple sclerosis can frequently induce systemic side effects such as flu-like symptoms with fever. In vitro stimulation of peripheral blood leukocytes with interferon-beta1b before the beginning of therapy shows that patients who develop fever generally have increased levels of interleukin-6.
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ISSN:0340-5354
1432-1459
DOI:10.1007/s004150050580