Gamma irradiation-induced liver injury and its amelioration by red ginseng extract

Radiation therapy is associated with liver damage and late liver injury. The hepatoprotective effect of Korean Red Ginseng (KRG) was determined in whole-body gamma-irradiated (γIR) mice. KRG at a dose of 10 and 50 mg/kg body weight was administrated to male C57BL/6 mice (each group, n=5) intraperito...

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Published inMolecular & cellular toxicology Vol. 13; no. 4; pp. 461 - 469
Main Authors Jang, Seon-A, Lee, Sung Ryul, Koo, Hyun Jung, Lee, Jin Woo, Park, Yuna, Namkoong, Seung, Kim, Myung Kyum, Kang, Se Chan, Sohn, Eun-Hwa
Format Journal Article
LanguageEnglish
Published Incheon The Korean Society of Toxicogenomics and Toxicoproteomics 01.12.2017
Springer Nature B.V
대한독성 유전단백체 학회
Subjects
Alanine
Alanine transaminase
Alkaline phosphatase
Aspartate aminotransferase
Biomedical and Life Sciences
Body weight
Cell Biology
Cyclooxygenase-2
Extracellular signal-regulated kinase
Fibrosis
Ginseng
Life Sciences
Liver
NF-κB protein
Original Paper
Pharmacology/Toxicology
Transforming growth factor-b1
Tumors
생물학
Korean Red Ginseng
Gamma-irradiation
Liver fibrosis
Cyclooxygenase-2
Tumour growth factor
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Summary:Radiation therapy is associated with liver damage and late liver injury. The hepatoprotective effect of Korean Red Ginseng (KRG) was determined in whole-body gamma-irradiated (γIR) mice. KRG at a dose of 10 and 50 mg/kg body weight was administrated to male C57BL/6 mice (each group, n=5) intraperitoneally for five days before whole-body γIR (6.5 Gy). Three days after γIR, serum and liver tissue were collected and analysed. Pretreatment with KRG suppressed serum alkaline phosphatase (ALP), alkaline aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl-transferase (GGT) activities. It also caused a marked increase in cyclooxygenase-2 (COX-2) and tumour growth factor-β1 (TGF-β1) expression associated nuclear factor-κB (NF-κB) activation in the liver. Extracellular signal-regulated kinases (ERKs) were also activated by irradiation. KRG treatment before irradiation could strongly suppress COX-2, TGF-β1, and ERK activation in the liver. Pretreatment with KRG may alleviate the severity of radiation-induced liver injury and fibrosis.
ISSN:1738-642X
2092-8467
DOI:10.1007/s13273-017-0050-5