c-Jun N-terminal kinase signaling in aging

Aging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities. However, the precise underlying mechanisms, particularly the involvement of specific molecular regulatory proteins in the aging process...

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Published inFrontiers in aging neuroscience Vol. 16; p. 1453710
Main Authors Li, Yihao, You, Li, Nepovimova, Eugenie, Adam, Vojtech, Heger, Zbynek, Jomova, Klaudia, Valko, Marian, Wu, Qinghua, Kuca, Kamil
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.08.2024
Subjects
aging
Aging Neuroscience
JNK
longevity
molecular insights
therapeutic targets
longevity
aging
therapeutic targets
molecular insights
JNK
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Summary:Aging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities. However, the precise underlying mechanisms, particularly the involvement of specific molecular regulatory proteins in the aging process, remain insufficiently understood. Emerging evidence indicates that c-Jun N-terminal kinase (JNK) serves as a potential regulator within the intricate molecular clock governing aging-related processes. JNK demonstrates the ability to diminish telomerase reverse transcriptase activity, elevate β-galactosidase activity, and induce telomere shortening, thereby contributing to immune system aging. Moreover, the circadian rhythm protein is implicated in JNK-mediated aging. Through this comprehensive review, we meticulously elucidate the intricate regulatory mechanisms orchestrated by JNK signaling in aging processes, offering unprecedented molecular insights with significant implications and highlighting potential therapeutic targets. We also explore the translational impact of targeting JNK signaling for interventions aimed at extending healthspan and promoting longevity.
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Reviewed by: Derek Schreihofer, University of North Texas Health Science Center, United States
Edited by: Meharvan Singh, Loyola University Chicago, United States
Mariaelena Repici, Aston University, United Kingdom
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2024.1453710