The immunobiology of myelodysplastic neoplasms: a mini-review

This mini review summarizes the immunobiology of myelodysplastic syndromes, specifically focusing on the interactions between immune cells, cytokines, and dysplastic cells within the tumor microenvironment in the bone marrow. We elucidate in detail how immune dysregulation and evasion influence the...

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Published inFrontiers in immunology Vol. 15; p. 1419807
Main Authors Kannan, Shruthi, Vedia, Rolando A, Molldrem, Jeffrey J
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.09.2024
Subjects
Animals
Bone Marrow - immunology
Bone Marrow - pathology
Cytokines - immunology
Cytokines - metabolism
Disease Progression
Humans
immune dysfunction
immunobiology
Immunology
immunomodulatory therapies
myelodysplastic neoplasms
myelodysplastic syndromes
Myelodysplastic Syndromes - immunology
Myelodysplastic Syndromes - therapy
Tumor Microenvironment - immunology
immune dysfunction
immunomodulatory therapies
immunobiology
myelodysplastic neoplasms
myelodysplastic syndromes
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Summary:This mini review summarizes the immunobiology of myelodysplastic syndromes, specifically focusing on the interactions between immune cells, cytokines, and dysplastic cells within the tumor microenvironment in the bone marrow. We elucidate in detail how immune dysregulation and evasion influence the initiation and progression of myelodysplastic syndromes, as well as resistance to therapy and progression to AML. In addition, we highlight a range of therapeutic strategies, including the most recent breakthroughs and experimental therapies for treating MDS. Finally, we address the existing knowledge gaps in the understanding of the immunobiology of MDS and propose future research directions, promising advancements toward enhancing clinical outcomes and survival for patients with MDS.
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Reviewed by: Vadim V. Sumbayev, University of Kent, United Kingdom
Edited by: Shyam Patel, University of Massachusetts Medical School, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1419807