Thermoregulatory responses elicited by microinjection of l -glutamate and its interaction with thermogenic effects of GABA and prostaglandin E2 in the preoptic area

Highlights ► Activation of the lateral preoptic area (POA) elicits heat loss responses. ► Inhibition of its central part evokes heat production. ► Activation of the rostromedial POA evokes biphasic changes in thermogenesis. ► The locus that is highly sensitive to prostaglandin E2 is unreactive to gl...

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Bibliographic Details
Published inNeuroscience Vol. 226; pp. 156 - 164
Main Author Osaka, T
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 13.12.2012
Subjects
Animals
Body Temperature Regulation - drug effects
Dinoprostone - pharmacology
gamma-Aminobutyric Acid - pharmacology
Glutamic Acid - pharmacology
heat loss
hypothalamus
Hypothalamus - physiology
Male
Microinjections
Neurology
Preoptic Area - drug effects
prostaglandin E2
rat
Rats
Rats, Wistar
Regional Blood Flow - drug effects
skin vasodilation
Tail - blood supply
thermoregulation
Vasodilation - drug effects
skin temperature of the tail
PGE 2
OVLT
MPO
T c
colonic temperature
prostaglandin E 2
heat loss
glutamate
POA
VO 2
MnPO
rat
T s
medial preoptic area
medial preoptic nucleus
preoptic area
thermoregulation
median preoptic nucleus
organum vasculosum of the lamina terminalis
skin vasodilation
rate of whole-body O 2 consumption
hypothalamus
sodium l-glutamate
MPA
PGE2
Tc
prostaglandin E2
VO2
Ts
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Summary:Highlights ► Activation of the lateral preoptic area (POA) elicits heat loss responses. ► Inhibition of its central part evokes heat production. ► Activation of the rostromedial POA evokes biphasic changes in thermogenesis. ► The locus that is highly sensitive to prostaglandin E2 is unreactive to glutamate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.08.048