Analytical applications of single particle inductively coupled plasma mass spectrometry: a comprehensive and critical review

Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) refers to the use of ICP-MS as a particle counting technique. When ICP-MS measurements are performed at very high data acquisition frequencies, information about (nano)particles containing specific elements and their dissolved...

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Published inAnalytical methods Vol. 13; no. 25; pp. 2742 - 2795
Main Authors Bolea, Eduardo, Jimenez, Maria S, Perez-Arantegui, Josefina, Vidal, Juan C, Bakir, Mariam, Ben-Jeddou, Khaoula, Gimenez-Ingalaturre, Ana C, Ojeda, David, Trujillo, Celia, Laborda, Francisco
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 07.07.2021
Subjects
Data acquisition
Emission spectroscopy
Hybridization
Immunoassay
Inductively coupled plasma mass spectrometry
Mass spectrometry
Mass spectroscopy
Nanoparticles
Reviews
Scientific imaging
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Summary:Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) refers to the use of ICP-MS as a particle counting technique. When ICP-MS measurements are performed at very high data acquisition frequencies, information about (nano)particles containing specific elements and their dissolved forms can be obtained (element mass per particle, size and number and mass concentrations). As a result of its outstanding performance, SP-ICP-MS has become a relevant technique for the analysis of complex samples containing inorganic nanoparticles. This review discusses the maturity level achieved by the technique through the methods developed for the detection, characterisation and quantification of engineered and natural (nano)particles. The application of these methods in different analytical scenarios is comprehensively reviewed and critically discussed, with special attention to their current technical and metrological limitations. The emergent applications of SP-ICP-MS in the field of nanoparticle-tagged immunoassay and hybridization methods are also reviewed. Real-world applications of single-particle ICP-MS are comprehensively and critically reviewed.
Bibliography:The authors belong to the Group of Analytical Spectroscopy and Sensors (GEAS) of the University of Zaragoza. The main research area of the group lies in the development and application of analytical techniques and methods in Nanometrology for the detection, characterization and quantification of natural and engineered nanoparticles. The group has made significant contributions in single particle ICP-MS and flow field flow fractionation hyphenated to ICP-MS. The authors have a long experience in these techniques but also in hydrodynamic chromatography, electron microscopy, as well as X-ray and electroanalytical techniques, which leads to a broad analytical platform for solving complex problems involving nanoparticles and colloids. The group has more than 10 year of experience and 40 publications in this field of Analytical Nanometrology.
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ISSN:1759-9660
1759-9679
DOI:10.1039/d1ay00761k