In Vitro and Ex Vivo Models - The Tumor Microenvironment in a Flask

Experimental tumor modeling has long supported the discovery of fundamental mechanisms of tumorigenesis and tumor progression, as well as provided platforms for the development of novel therapies. Still, the attrition rates observed today in clinical translation could be, in part, mitigated by more...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 1219; p. 431
Main Authors Pinto, Catarina, Estrada, Marta F, Brito, Catarina
Format Journal Article
LanguageEnglish
Published United States 2020
Subjects
Drug Evaluation, Preclinical
Humans
In Vitro Techniques
Models, Biological
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Tumor Microenvironment - drug effects
Experimental tumor modeling
Cancer models
Tumor explants
Tumor microenvironment
3D cell cultures
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Summary:Experimental tumor modeling has long supported the discovery of fundamental mechanisms of tumorigenesis and tumor progression, as well as provided platforms for the development of novel therapies. Still, the attrition rates observed today in clinical translation could be, in part, mitigated by more accurate recapitulation of environmental cues in research and preclinical models. The increasing understanding of the decisive role that tumor microenvironmental cues play in the outcome of drug response urges its integration in preclinical tumor models. In this chapter we review recent developments concerning in vitro and ex vivo approaches.
ISSN:0065-2598
DOI:10.1007/978-3-030-34025-4_23