New Metabolites of Rhodiola rosea I. Glycosides of Herbacetin and Gossypetin

• Published in: Chemistry of natural compounds Vol. 58; no. 6; pp. 1014 - 1020
• Main Authors: Olennikov, D. N., Chirikova, N. K.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2022; Springer Nature; Springer; Springer Nature B.V
• Subjects: Bioflavonoids; Chemistry; Chemistry and Materials Science; Chemistry, Medicinal; Chemistry, Organic; Chemistry/Food Science; Flavones; Flavonoids; Glycosides; Life Sciences & Biomedicine; Mass spectrometry; Metabolites; NMR; Nuclear magnetic resonance; Organic Chemistry; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; Science & Technology; Spectrometry; amylase inhibitors; gossypetin; herbacetin; antioxidants; Crassulaceae; flavonol; glucosides; alpha-amylase inhibitors; flavonol O-glucosides; Rhodiola rosea
• ISSN: 0009-3130; 1573-8388
• DOI: 10.1007/s10600-022-03857-w

New O-glycosides of herbacetin and gossypetin ( 1 – 6 ) and eight known compounds were isolated from leaves of Rhodiola rosea L. [ Sedum roseum (L.) Scop., Crassulaceae]. According to UV, IR, and NMR spectroscopic and mass spectrometric data, the isolated compounds were herbacetin-3-O-(3′′ -O-malonyl)- β -Dglucopyranoside-7-O- β -D-glucopyranoside-8-O- β -D-glucuronopyranoside (rhodirosin A, 1 ), herbacetin- 3-O-(3′′,4′′-di-O-acetyl)- β -D-glucopyranoside-8-O- β -D-glucuronopyranoside (rhodirosin B, 2 ), gossypetin- 8-O-(2′′-O-malonyl)- β -D-glucuronopyranoside (rhodirosin C, 3 ), gossypetin-8-O-(2′′-O-acetyl)- β -Dglucuronopyranoside (rhodirosin D, 4 ), herbacetin-8-O-(2′′-O-malonyl)- β -D-glucuronopyranoside (rhodirosin E, 5 ), and herbacetin-8-O-(2′′ -O-acetyl)- β -D-glucuronopyranoside (rhodirosin F, 6 ). Flavonoids 3 and 4 possessed the highest antiradical activity and inhibited the activity of α -amylase.