Plasma and tissue iron changes in the rat after acute administration of ethionine

1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron cle...

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Bibliographic Details
Published inClinical and experimental pharmacology & physiology Vol. 2; no. 6; p. 459
Main Authors Loh, T T, Archdeacon, J W
Format Journal Article
LanguageEnglish
Published Australia 01.12.1975
Subjects
Animals
Erythrocytes - drug effects
Erythrocytes - metabolism
Ethionine - antagonists & inhibitors
Ethionine - pharmacology
Female
Iron - blood
Iron - metabolism
Liver - drug effects
Liver - metabolism
Osmotic Fragility - drug effects
Rats
Spleen - drug effects
Spleen - metabolism
Time Factors
Transferrin - metabolism
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Summary:1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron clearance. Erythrocytes of rats injected with ethionine show altered responses to hypertonicity. 3. Increased reticulo-endothelial activity of the spleen, indicated by increased uptake of 59Fe-labelled erythrocytes by liver and spleen, apparently contributes to plasma iron elevation. Also the liver releases iron which further raises plasma iron.
ISSN:0305-1870
DOI:10.1111/j.1440-1681.1975.tb01851.x