Combining the Pharmaceutical and Toxicological Properties of Selected Essential Oils with their Chemical Components by GC‐MS Analysis

In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis, Pelargonium graveolens, Thymus vulgaris, Origanum vulgare, Laurus nobilis, and Aloysia citrodora. An exploration was conducted into...

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Published inChemistry & biodiversity Vol. 21; no. 7; pp. e202400738 - n/a
Main Authors Nilofar, Ahmed, Shakeel, Zengin, Gokhan, Di Simone, Simonetta Cristina, Acquaviva, Alessandra, Libero, Maria Loreta, Chiavaroli, Annalisa, Orlando, Giustino, Tacchini, Massimo, Di Vito, Maura, Menghini, Luigi, Ferrante, Claudio
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.07.2024
Subjects
Allelopathy
Anticancer properties
Antioxidant effects
Antioxidants
Antitumor activity
Aromatic plants
Cancer
Chemical composition
Colorectal cancer
Colorectal carcinoma
Cytotoxicity
Enzyme inhibition
Essential oils
Gas chromatography
Gene expression
Glucosidase
Mass spectrometry
Mass spectroscopy
Oils & fats
Oregano
Plant extracts
Plant species
Supply chains
α-Amylase
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Abstract In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis, Pelargonium graveolens, Thymus vulgaris, Origanum vulgare, Laurus nobilis, and Aloysia citrodora. An exploration was conducted into the chemical composition using Gas Chromatography‐Mass Spectrometry (GC/MS), antioxidant properties assessed through DPPH, ABTS, CUPRAC, FRAP, MCA, and PBD assays, ecotoxicological impacts evaluated via allelopathy and the Daphnia magna heartbeat test, as well as bio‐pharmacological effects including anticancer activity and gene expression analysis. Results revealed strong antioxidant activity in all essential oils, with T. vulgaris EO (2748.00 mg TE/g) and O. vulgare EO (2609.29 mg TE/g) leading in CUPRAC assay. R. officinalis EO showed the highest α‐amylase inhibition at 1.58 mmol ACAE/g, while O. vulgare EO excelled in α‐glucosidase inhibition at 1.57 mmol ACAE/g. Additionally, cytotoxic effects were evaluated on human colorectal cancer (HCT116) cells. A. citrodora, O. vulgare, and R. officinalis EOs were found the most potent anticancer, as also witnessed by their higher modulatory effects on the gene expression of BAX and Bcl‐2. Collectively, the present data highlight the importance to implement the knowledge and to valorize the supply chain of aromatic plants.
AbstractList In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis, Pelargonium graveolens, Thymus vulgaris, Origanum vulgare, Laurus nobilis, and Aloysia citrodora. An exploration was conducted into the chemical composition using Gas Chromatography‐Mass Spectrometry (GC/MS), antioxidant properties assessed through DPPH, ABTS, CUPRAC, FRAP, MCA, and PBD assays, ecotoxicological impacts evaluated via allelopathy and the Daphnia magna heartbeat test, as well as bio‐pharmacological effects including anticancer activity and gene expression analysis. Results revealed strong antioxidant activity in all essential oils, with T. vulgaris EO (2748.00 mg TE/g) and O. vulgare EO (2609.29 mg TE/g) leading in CUPRAC assay. R. officinalis EO showed the highest α‐amylase inhibition at 1.58 mmol ACAE/g, while O. vulgare EO excelled in α‐glucosidase inhibition at 1.57 mmol ACAE/g. Additionally, cytotoxic effects were evaluated on human colorectal cancer (HCT116) cells. A. citrodora, O. vulgare, and R. officinalis EOs were found the most potent anticancer, as also witnessed by their higher modulatory effects on the gene expression of BAX and Bcl‐2. Collectively, the present data highlight the importance to implement the knowledge and to valorize the supply chain of aromatic plants.
In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis, Pelargonium graveolens, Thymus vulgaris, Origanum vulgare, Laurus nobilis, and Aloysia citrodora. An exploration was conducted into the chemical composition using Gas Chromatography-Mass Spectrometry (GC/MS), antioxidant properties assessed through DPPH, ABTS, CUPRAC, FRAP, MCA, and PBD assays, ecotoxicological impacts evaluated via allelopathy and the Daphnia magna heartbeat test, as well as bio-pharmacological effects including anticancer activity and gene expression analysis. Results revealed strong antioxidant activity in all essential oils, with T. vulgaris EO (2748.00 mg TE/g) and O. vulgare EO (2609.29 mg TE/g) leading in CUPRAC assay. R. officinalis EO showed the highest α-amylase inhibition at 1.58 mmol ACAE/g, while O. vulgare EO excelled in α-glucosidase inhibition at 1.57 mmol ACAE/g. Additionally, cytotoxic effects were evaluated on human colorectal cancer (HCT116) cells. A. citrodora, O. vulgare, and R. officinalis EOs were found the most potent anticancer, as also witnessed by their higher modulatory effects on the gene expression of BAX and Bcl-2. Collectively, the present data highlight the importance to implement the knowledge and to valorize the supply chain of aromatic plants.In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis, Pelargonium graveolens, Thymus vulgaris, Origanum vulgare, Laurus nobilis, and Aloysia citrodora. An exploration was conducted into the chemical composition using Gas Chromatography-Mass Spectrometry (GC/MS), antioxidant properties assessed through DPPH, ABTS, CUPRAC, FRAP, MCA, and PBD assays, ecotoxicological impacts evaluated via allelopathy and the Daphnia magna heartbeat test, as well as bio-pharmacological effects including anticancer activity and gene expression analysis. Results revealed strong antioxidant activity in all essential oils, with T. vulgaris EO (2748.00 mg TE/g) and O. vulgare EO (2609.29 mg TE/g) leading in CUPRAC assay. R. officinalis EO showed the highest α-amylase inhibition at 1.58 mmol ACAE/g, while O. vulgare EO excelled in α-glucosidase inhibition at 1.57 mmol ACAE/g. Additionally, cytotoxic effects were evaluated on human colorectal cancer (HCT116) cells. A. citrodora, O. vulgare, and R. officinalis EOs were found the most potent anticancer, as also witnessed by their higher modulatory effects on the gene expression of BAX and Bcl-2. Collectively, the present data highlight the importance to implement the knowledge and to valorize the supply chain of aromatic plants.
In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis , Pelargonium graveolens , Thymus vulgaris , Origanum vulgare, Laurus nobilis , and Aloysia citrodora . An exploration was conducted into the chemical composition using Gas Chromatography‐Mass Spectrometry (GC/MS), antioxidant properties assessed through DPPH, ABTS, CUPRAC, FRAP, MCA, and PBD assays, ecotoxicological impacts evaluated via allelopathy and the Daphnia magna heartbeat test, as well as bio‐pharmacological effects including anticancer activity and gene expression analysis. Results revealed strong antioxidant activity in all essential oils, with T. vulgaris EO (2748.00 mg TE/g) and O. vulgare EO (2609.29 mg TE/g) leading in CUPRAC assay. R. officinalis EO showed the highest α‐amylase inhibition at 1.58 mmol ACAE/g, while O. vulgare EO excelled in α‐glucosidase inhibition at 1.57 mmol ACAE/g. Additionally, cytotoxic effects were evaluated on human colorectal cancer (HCT116) cells. A. citrodora, O. vulgare , and R. officinalis EOs were found the most potent anticancer, as also witnessed by their higher modulatory effects on the gene expression of BAX and Bcl‐2. Collectively, the present data highlight the importance to implement the knowledge and to valorize the supply chain of aromatic plants.
Author Nilofar
Menghini, Luigi
Ahmed, Shakeel
Zengin, Gokhan
Libero, Maria Loreta
Di Simone, Simonetta Cristina
Chiavaroli, Annalisa
Ferrante, Claudio
Acquaviva, Alessandra
Orlando, Giustino
Tacchini, Massimo
Di Vito, Maura
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  organization: Semplici”, Università degli Studi “Gabriele d'Annunzio”
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Snippet In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus...
In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus...
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StartPage e202400738
SubjectTerms Allelopathy
Anticancer properties
Antioxidant effects
Antioxidants
Antitumor activity
Aromatic plants
Cancer
Chemical composition
Colorectal cancer
Colorectal carcinoma
Cytotoxicity
Enzyme inhibition
Essential oils
Gas chromatography
Gene expression
Glucosidase
Mass spectrometry
Mass spectroscopy
Oils & fats
Oregano
Plant extracts
Plant species
Supply chains
α-Amylase
Title Combining the Pharmaceutical and Toxicological Properties of Selected Essential Oils with their Chemical Components by GC‐MS Analysis
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbdv.202400738
https://www.proquest.com/docview/3081087987
https://www.proquest.com/docview/3050175638
Volume 21
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