Neolignans and Sesquiterpenoid from Piper yunnanense

Two biphenyl‐type neolignans with a rare dibenzofuran skeleton, including a new one piyunneolignan A (1) and a known one piperneolignan D (2), together with a new sesquiterpenoid piyunin A (3), were isolated from the leaves and twigs of Piper yunnanense. Their structures were established on the basi...

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Published inChemistry & biodiversity Vol. 18; no. 9; pp. e2100458 - n/a
Main Authors Chen, Yu‐Xi, You, Yun‐Xia, Rao, Li, Liu, Yu, He, Qian, Xu, You‐Kai, Lin, Bin, Zhang, Chuan‐Rui
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 01.09.2021
Subjects
Antiinfectives and antibacterials
Circular dichroism
Cytotoxicity
Data analysis
Dibenzofuran
dibenzofuran skeleton
Dichroism
ECD calculation
neolignans
Piper yunnanense
sesquiterpenoid
Tumor cell lines
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Summary:Two biphenyl‐type neolignans with a rare dibenzofuran skeleton, including a new one piyunneolignan A (1) and a known one piperneolignan D (2), together with a new sesquiterpenoid piyunin A (3), were isolated from the leaves and twigs of Piper yunnanense. Their structures were established on the basis of comprehensive spectroscopic data analysis and electronic circular dichroism (ECD) calculation. Piyunneolignan A (1) featured a rare C‐2−C‐2′/C‐3−O−C‐3′ linkage. Compounds 1–3 were evaluated for their antimicrobial and cytotoxic activities against a panel of bacteria, fungi, and human cancer cell lines, respectively.
Bibliography:Equal contribution.
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ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202100458