Neo‐clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L

• Published in: Chemistry & biodiversity Vol. 18; no. 9; pp. e2100517 - n/a
• Main Authors: Fan, Min, Wang, Ting, Peng, Li‐Yan, Huang, Jun‐Shang, Wu, Xing‐De, Wang, He‐Yao, Zhao, Qin‐Shi
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.09.2021
• Subjects: Absolute configuration; Blood glucose; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diterpenes; Glucose; Hypoglycemia; Insulin; Insulin resistance; Metformin; neo-clerodane diterpenoid; NMR; Nuclear magnetic resonance; Rodents; Salvia hispanica; salvihispin H; type 2 diabetes mellitus
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202100517

A new neo‐clerodane diterpenoid, salvihispin H (1), and six known ones (2–7) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (1H, 13C, and 2D NMR, and HR‐ESI‐MS) and single‐crystal X‐ray diffraction data. The anti‐diabetic effects of salvihispin H (1) and salvifaricin (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose‐lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM).