Cicatricial ectropion in a patient treated with dupilumab

To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injections for atopic dermatiti...

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Bibliographic Details
Published inAmerican journal of ophthalmology case reports Vol. 7; no. C; pp. 120 - 122
Main Authors Barnes, Alexander C, Blandford, Alexander D, Perry, Julian D
Format Journal Article
LanguageEnglish
Published United States Elsevier 01.09.2017
Subjects
Case report
Cicatricial ectropion
Conjunctivitis
Dupilumab
Ocular surface inflammation
Cicatricial ectropion
Conjunctivitis
Ocular surface inflammation
Dupilumab
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Summary:To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injections for atopic dermatitis. The findings worsened over the next several months and improved after discontinuing dupilumab. Dupilumab is a promising intervention in the management of atopic dermatitis and asthma, however, little is known about its potential ocular adverse effects. We report the first case of dupilumab-associated ocular inflammation leading to cicatricial ectropion.
ISSN:2451-9936
2451-9936
DOI:10.1016/j.ajoc.2017.06.017