In vivo non‐contact measurement of human iris elasticity by optical coherence elastography
Quantifying the mechanical properties of the iris can offer valuable insights into the pathophysiology of primary angle closure glaucoma. However, current techniques for iris elastography remain ex vivo with limited clinical applications. This article describes a proposition for a non‐contact and no...
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Published in | Journal of biophotonics Vol. 14; no. 9; pp. e202100116 - n/a |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY‐VCH Verlag GmbH & Co. KGaA
01.09.2021
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Quantifying the mechanical properties of the iris can offer valuable insights into the pathophysiology of primary angle closure glaucoma. However, current techniques for iris elastography remain ex vivo with limited clinical applications. This article describes a proposition for a non‐contact and non‐invasive air‐puff optical coherence elastography (OCE) system that can evaluate iris elasticity in vivo. Ten eyes recruited from seven subjects underwent OCE imaging acquisition under three different illumination conditions. The Young's modulus of each eye was detected and shown to be inversely proportional to the iris length, indicating a relationship between mechanical properties and morphology of the iris. With its noninvasive and high‐resolution features, this air‐puff system shows great potential for applications in clinical ophthalmology.
The non‐contact air‐puff OCE system is developed to evaluate iris elasticity in vivo with high repeatability. Ten subject eyes was recruited and underwent OCE imaging acquisition under three different illumination conditions. The mean Young's modulus of each group was shown to be inversely proportional to the iris length. |
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Bibliography: | Funding information National Key R&D Program of China, Grant/Award Number: 2020YFC2008200 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1864-063X 1864-0648 |
DOI: | 10.1002/jbio.202100116 |