Vancomycin‐Functionalized Porphyrinic Metal‐Organic Framework PCN‐224 with Enhanced Antibacterial Activity against Staphylococcus Aureus

A vancomycin (Van) modification strategy on a porphyrinic metal‐organic framework (MOF) PCN‐224 is presented. The obtained Van‐PCN‐224 gives the combined advantages of porphyrinic MOF and Van with high photosensitive activity and excellent targeted antibacterial activity against Staphylococcus aureu...

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Published inChemistry, an Asian journal Vol. 16; no. 15; pp. 2022 - 2026
Main Authors Chen, Li‐Jian, Liu, Yao‐Yao, Zhao, Xu, Yan, Xiu‐Ping
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 02.08.2021
Subjects
Antibacterial ability
Antibiotics
Chemistry
Metal-organic frameworks
Photosensitivity
Porphyrinic Metal-Organic Framework
Vancomycin
Vancomycin functionalization
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Summary:A vancomycin (Van) modification strategy on a porphyrinic metal‐organic framework (MOF) PCN‐224 is presented. The obtained Van‐PCN‐224 gives the combined advantages of porphyrinic MOF and Van with high photosensitive activity and excellent targeted antibacterial activity against Staphylococcus aureus. The features make Van‐PCN‐224 promising for antimicrobial therapy. Vancomycin‐functionalized porphyrinic metal‐organic framework PCN‐224 displays the integrated merits of the bacteria‐targeting ability of vancomycin and the photodynamic effect of PCN‐224 for enhanced targeted sterilization.
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ISSN:1861-4728
1861-471X
1861-471X
DOI:10.1002/asia.202100546