A synthetic calcium-chelating L-glutamyl-L-serine phosphate (Glu-Ser.P) enhances calcium absorption in the rat

A new synthetic procedure was used to prepare L-glutamyl-L-serine phosphate (Glu-Ser.P) with a good yield. The phosphopeptide is able to chelate calcium ion as shown by conductimetric titration and through the use of a calcium-specific electrode. Intestinal absorption of radioactive calcium is enhan...

Full description

Saved in:
Bibliographic Details
Published inThe journal of peptide research Vol. 52; no. 1; pp. 15 - 18
Main Authors Galzigna, L, Domergue, N, Previero, A
Format Journal Article
LanguageEnglish
Published COPENHAGEN Wiley 01.07.1998
Subjects
Administration, Oral
Animals
Biochemical Research Methods
Biochemistry & Molecular Biology
Calcium - metabolism
Calcium Radioisotopes - metabolism
Chelating Agents - chemistry
Dipeptides - chemistry
Electric Conductivity
Intestinal Absorption - drug effects
Life Sciences & Biomedicine
Phosphopeptides - chemistry
Rats
Science & Technology
SOLID-PHASE
intestinal calcium absorption
calcium chelation
rat
PHOSPHOPEPTIDES
L-glutamyl-L-serine phosphate
Online AccessGet more information

Cover

More Information
Summary:A new synthetic procedure was used to prepare L-glutamyl-L-serine phosphate (Glu-Ser.P) with a good yield. The phosphopeptide is able to chelate calcium ion as shown by conductimetric titration and through the use of a calcium-specific electrode. Intestinal absorption of radioactive calcium is enhanced in rats fed Ca-45 and Glu-Ser.P.
ISSN:1397-002X
DOI:10.1111/j.1399-3011.1998.tb00647.x