Alpha-thalassaemia in Nigeria: its interaction with sickle-cell disease
We have determined the molecular basis and frequency of alpha-thalassaemia in Nigeria. The alpha-thalassaemia determinant in this population is caused by only one type of single alpha globin gene deletion (-alpha 3.7). Comparison of the haematological features of those patients who have sickle-cell...
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Published in | European journal of haematology Vol. 38; no. 4; p. 370 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
01.04.1987
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Subjects | |
Online Access | Get more information |
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Summary: | We have determined the molecular basis and frequency of alpha-thalassaemia in Nigeria. The alpha-thalassaemia determinant in this population is caused by only one type of single alpha globin gene deletion (-alpha 3.7). Comparison of the haematological features of those patients who have sickle-cell disease with (-alpha/alpha alpha, -alpha/-alpha) or without (alpha alpha/alpha alpha) alpha-thalassaemia showed similar trends to those reported in Jamaican and U.S. patients with these interactions. However, in contrast to studies in some other African populations we have shown that the frequency of alpha-thalassaemia in Nigeria is the same (0.24) in patients with or without homozygous sickle-cell disease (AA, AS and AC genotypes). |
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ISSN: | 0902-4441 1600-0609 |
DOI: | 10.1111/j.1600-0609.1987.tb00013.x |