Alpha-thalassaemia in Nigeria: its interaction with sickle-cell disease

We have determined the molecular basis and frequency of alpha-thalassaemia in Nigeria. The alpha-thalassaemia determinant in this population is caused by only one type of single alpha globin gene deletion (-alpha 3.7). Comparison of the haematological features of those patients who have sickle-cell...

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Bibliographic Details
Published inEuropean journal of haematology Vol. 38; no. 4; p. 370
Main Authors Falusi, A G, Esan, G J, Ayyub, H, Higgs, D R
Format Journal Article
LanguageEnglish
Published England 01.04.1987
Subjects
Adolescent
Adult
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - genetics
Child
Chromosome Deletion
Erythrocyte Indices
Female
Genetics, Population
Genotype
Globins - genetics
Humans
Male
Nigeria
Thalassemia - complications
Thalassemia - epidemiology
Thalassemia - genetics
Nigeria
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Summary:We have determined the molecular basis and frequency of alpha-thalassaemia in Nigeria. The alpha-thalassaemia determinant in this population is caused by only one type of single alpha globin gene deletion (-alpha 3.7). Comparison of the haematological features of those patients who have sickle-cell disease with (-alpha/alpha alpha, -alpha/-alpha) or without (alpha alpha/alpha alpha) alpha-thalassaemia showed similar trends to those reported in Jamaican and U.S. patients with these interactions. However, in contrast to studies in some other African populations we have shown that the frequency of alpha-thalassaemia in Nigeria is the same (0.24) in patients with or without homozygous sickle-cell disease (AA, AS and AC genotypes).
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.1987.tb00013.x