Hydrogel Composites with Different Dimensional Nanoparticles for Bone Regeneration

• Published in: Macromolecular rapid communications. Vol. 42; no. 20; pp. e2100362 - n/a
• Main Authors: Li, Xingchen, Yang, Zhe, Fang, Linan, Ma, Chengyuan, Zhao, Yue, Liu, Hou, Che, Songtian, Zvyagin, Andrei V., Yang, Bai, Lin, Quan
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.10.2021
• Subjects: Adaptability; Biocompatibility; Biological materials; Biological properties; biomaterials; Bone growth; bone tissue regeneration; Defects; Drug delivery; Fractures; Hydrogels; Nanoparticles; Orthopedics; Regeneration; Regeneration (physiology); Trauma; Tumors
• ISSN: 1022-1336; 1521-3927
• DOI: 10.1002/marc.202100362

The treatment of large segmental bone defects and complex types of fractures caused by trauma, inflammation, or tumor resection is still a challenge in the field of orthopedics. Various natural or synthetic biological materials used in clinical applications cannot fully replicate the structure and performance of raw bone. This highlights how to endow materials with multiple functions and biological properties, which is a problem that needs to be solved in practical applications. Hydrogels with outstanding biocompatibility, for their casting into any shape, size, or form, are suitable for different forms of bone defects. Therefore, they have been used in regenerative medicine more widely. In this review, versatile hydrogels are compounded with nanoparticles of different dimensions, and many desirable features of these materials in bone regeneration are introduced, including drug delivery, cell factor vehicle, cell scaffolds, which have potential in bone regeneration applications. The combination of hydrogels and nanoparticles of different dimensions encourages better filling of bone defect areas and has higher adaptability. This is due to the minimally invasive properties of the material and ability to match irregular defects. These biological characteristics make composite hydrogels with different dimensional nanoparticles become one of the most attractive options for bone regeneration materials. Versatile hydrogels are compounded with nanoparticles of different dimensions, and many desirable features of these materials in bone regeneration are introduced, including drug delivery, cell factor vehicles, and cell scaffolds, which have potential in bone regeneration applications.