Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, whic...

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Published inNanoscale Vol. 9; no. 43; pp. 16622 - 16626
Main Authors Mauriello-Jimenez, Chiara, Henry, Maxime, Aggad, Dina, Raehm, Laurence, Cattoën, Xavier, Wong Chi Man, Michel, Charnay, Clarence, Alpugan, Serkan, Ahsen, Vefa, Tarakci, Deniz Kutlu, Maillard, Philippe, Maynadier, Marie, Garcia, Marcel, Dumoulin, Fabienne, Gary-Bobo, Magali, Coll, Jean-Luc, Josserand, Véronique, Durand, Jean-Olivier
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2017
Subjects
Chemical Sciences
Fluorescence
Imaging
Material chemistry
Nanoparticles
Organic chemistry
Photodynamic therapy
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Summary:Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, which in contrast displayed a very high signal for photoacoustic imaging in mice.
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ISSN:2040-3364
2040-3372
DOI:10.1039/c7nr04677d