Invasion and distribution of methanol

• Published in: Archives of toxicology Vol. 74; no. 6; pp. 313 - 321
• Main Authors: GRAW, M, HAFFNER, H.-T, ALTHAUS, L, BESSERER, K, VOGES, S
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.08.2000
• Subjects: Administration, Oral; Adult; Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; Drug Interactions; Ethanol - pharmacology; Half-Life; Humans; Injections, Intravenous; Male; Medical sciences; Methanol - administration & dosage; Methanol - pharmacokinetics; Tissue Distribution; Toxicology; Various organic compounds; Human; Toxicokinetics; Healthy subject; Distribution; Oral administration; Pharmacokinetics; Parenteral administration; Half life; Methanol
• ISSN: 0340-5761; 1432-0738
• DOI: 10.1007/s002040000107

After the enzyme systems responsible for methanol oxidation were blocked by ethanol, five test persons were given methanol at a dose of approximately 10 mg/kg weight, once orally and once parenterally. Taking into account the endogenous blood methanol levels detectable before the administration of methanol, C0 concentrations of 11.1-15.9 mg/kg were reached. This corresponds to a distribution volume of approximately 0.77 +/- 0.07 l/kg, which is comparable to the 0.78 +/- 0.09 l/kg obtained for ethanol. After parenterally administering methanol as a bolus, the distribution half-life was on average 8 min (range: 3.8-13.8 min). After oral administration of methanol diluted in 100 ml water on an empty stomach, invasion took place with a half-life of approximately 5 min (3.8-6.9 min). In one case, however, due to vegetative disturbances the invasion half-life was 23.1 min.