Effect of selank on the main carboxypeptidases in the rat nervous tissue

Effect of single selank administration on activity of carboxypeptidase H (CPH) and of phenylmethylsulfonylfluoride-inhibited carboxypeptidase (PMSP-CP)—the enzymes detaching arginine and lysine from C-terminus of molecules-precursors of biologically active peptides was studied. The preparation has b...

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Published inJournal of evolutionary biochemistry and physiology Vol. 48; no. 3; pp. 306 - 309
Main Authors Solov’ev, B. V., Gengin, M. T., Sollertinskaya, T. N., Latynova, I. V., Zhigaeva, L. V.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.05.2012
Springer Nature B.V
Subjects
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Comparative and Ontogenic Physiology
Enzymes
Evolutionary Biology
Life Sciences
Molecular biology
Peptides
Rodents
Tissues
neuropeptides
selank
brain
basic carboxypeptidases
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Summary:Effect of single selank administration on activity of carboxypeptidase H (CPH) and of phenylmethylsulfonylfluoride-inhibited carboxypeptidase (PMSP-CP)—the enzymes detaching arginine and lysine from C-terminus of molecules-precursors of biologically active peptides was studied. The preparation has been shown to cause long, preserved for 24 h changes of activities of these carboxypeptidases. It is suggested that the change in activity of the studied enzymes can be one of the mechanisms of regulation of level of neuropeptides at action of selank.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093012030073