Formulation and evaluation of bucco-adhesive tablets of sumatriptan succinate

• Published in: International Journal of Pharmaceutical Investigation Vol. 1; no. 3; pp. 182 - 191
• Main Authors: Prasanna, R Indira, Anitha, P, Chetty, C Madhusudhana
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.07.2011; Medknow Publications & Media Pvt Ltd
• Subjects: Analysis; Drug therapy; Health aspects; Migraine; Original; Sumatriptan; India; Carbopol 934P; sumatriptan succinate; Bucco-adhesive tablet; sodium carboxy methyl cellulose; migraine; ex vivo permeation studies; ethyl cellulose; HPMC K4M
• ISSN: 2230-973X; 2230-9713
• DOI: 10.4103/2230-973X.85971

A novel aspiration in treatment of migraine, to provide greater therapeutic effect, overcome the side effects by complex therapeutic regimen and to improve patient compliance upon administering bucco-adhesive tablet formulations of sumatriptan succinate which have not been tested literally. This study was designed to develop a bucco-adhesive tablet containing sumatriptan succinate using blends of different bio-adhesive polymeric combinations such as hydroxy propyl methyl cellulose K4M, sodium carboxy methyl cellulose, and Carbopol 934P with a backing layer of ethyl cellulose by a direct compression technique. Tablets were subjected to physico-chemical parameters, swelling index, surface pH, ex vivo bioadhesive force, in vitro drug release, ex vivo drug permeation, and stability in saliva. Good results were obtained in all the evaluated parameters. The drug release of all formulation follows zero-order kinetics by a diffusion mechanism type. Stability studies in human saliva, ex vivo buccal permeation studies by using sheep and porcine buccal mucosa were carried out for the optimized formulation (S4 CP:HPMC 3:1). The developed buccal drug delivery system containing sumatriptan succinate might be the alternative routes available to bypass the first pass metabolism and might be a milestone in the therapy of migraine and among all formulations S4 shows good controlled release results correlated with ex vivo permeation studies.