Association of stromal-derived factor-1 alpha and endogenous sex hormones in men aged over 50 years with stable coronary artery disease

• Published in: Advances in medical sciences Vol. 57; no. 2; pp. 322 - 327
• Main Authors: Barud, W, Nasiłowska-Barud, A, Sobstyl, J, Mieczkowska, J, Wójcicka, G, Bełtowski, J, Myśliński, W, Mosiewicz, J
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Urban & Partner Sp. z o.o 01.12.2012; Versita; Elsevier Limited
• Subjects: Aged; Chemokine CXCL12 - blood; coronary artery disease; Coronary Artery Disease - blood; Cross-Sectional Studies; Estradiol - blood; Gonadal Steroid Hormones - blood; Humans; Male; men; Middle Aged; Risk Factors; SDF-1 alpha; Sex Hormone-Binding Globulin - metabolism; sex hormones; Testosterone - blood; coronary artery disease; sex hormones; SDF-1 alpha; men
• ISSN: 1896-1126; 1898-4002
• DOI: 10.2478/v10039-012-0051-5

Many studies indicate an inverse relationship between stromal-derived factor-1 alpha (SDF-1 alpha), a chemokine, and coronary risk factors. Moreover, SDF-1 alpha is crucial in neoangiogenesis and in the mobilization and homing of endothelial progenitor cells to the ischemic coronary vessels. Numerous studies indicate that circulating sex hormones are associated with atherogenesis during male aging. The aim of this study was therefore to determine whether there exists a relationship between SDF-1 alpha and endogenous sex hormones in aging men with stable coronary artery disease (CAD). Plasma concentrations of SDF-1 alpha, testosterone (T), estradiol (E2), and sex hormone binding globulin (SHBG) were measured and the E2/T ratio was calculated in a cross-sectional study of 82 men over 50 years of age with stable CAD. SDF-1 alpha was positively and significantly correlated with T (r = 0.233; p = 0.036) and with SHBG (r = 0.312; p = 0.004). There was a significant inverse correlation between SDF-1 alpha and the E2/T ratio (r = -0.463; p < 0.001). After adjustment for age, body mass index and smoking status, SHBG and E2/T ratio were the only factors associated with SDF-1 alpha. T and SHBG (directly) and the E2/T ratio (inversely) may be involved in the etiopathogenesis of CAD through their relationships to SDF-1 alpha.