Cognitive and molecular aspects of fragile X

The relationships among parental origin of the fragile X gene, gene structure, and specific cognitive deficits were evaluated in nonretarded adult female fragile X carriers to determine whether: (1) origin influences gene structure and cognitive function, (2) mild cognitive impairments are associate...

Full description

Saved in:
Bibliographic Details
Published inJournal of clinical and experimental neuropsychology Vol. 17; no. 4; p. 518
Main Authors Hinton, V J, Halperin, J M, Dobkin, C S, Ding, X H, Brown, W T, Miezejeski, C M
Format Journal Article
LanguageEnglish
Published England 01.08.1995
Subjects
Adult
Attention - physiology
Cognition Disorders - genetics
Cognition Disorders - psychology
Female
Fragile X Syndrome - genetics
Fragile X Syndrome - psychology
Genetic Carrier Screening
Genetic Linkage - genetics
Humans
Intellectual Disability - genetics
Intellectual Disability - psychology
Male
Mental Recall - physiology
Middle Aged
Models, Genetic
Neuropsychological Tests
Pedigree
Phenotype
Psychomotor Performance - physiology
Online AccessGet more information

Cover

More Information
Summary:The relationships among parental origin of the fragile X gene, gene structure, and specific cognitive deficits were evaluated in nonretarded adult female fragile X carriers to determine whether: (1) origin influences gene structure and cognitive function, (2) mild cognitive impairments are associated with altered gene structure, and (3) specific cognitive domains are affected. Results indicated that 56% of women with maternally inherited, but none with paternally inherited, fragile X showed large genomic structural alterations and selective deficits on measures of visual attention. Thus, molecular status of the fragile X gene appears to be linked to parental origin and may selectively affect specific cognitive skills.
ISSN:1380-3395
DOI:10.1080/01688639508405142