Synthesis, structures, and Helicobacter Pylori urease inhibition of hydroxamate-coordinated oxovanadium complexes with benzohydrazone ligands

• Published in: Transition metal chemistry (Weinheim) Vol. 39; no. 3; pp. 291 - 297
• Main Authors: Cheng, Xiao-Shan, Zhang, Ji-Cai, You, Zhong-Lu, Wang, Xue, Li, Hai-Hua
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2014; Springer Nature B.V
• Subjects: Catalysis; Chemistry; Chemistry and Materials Science; Helicobacter pylori; Inorganic Chemistry; Organometallic Chemistry; Physical Chemistry; Thermal Gravimetric Analysis; Molecular Docking Study; Cambridge Crystallographic Data Centre; Docking Score; Oxovanadium
• ISSN: 0340-4285; 1572-901X
• DOI: 10.1007/s11243-014-9802-4

A new acetohydroxamate-coordinated oxovanadium(V) complex, [VOL(AE)] ( 1 ), and a new benzohydroxamate-coordinated oxovanadium(V) complex, [VOL(BE)] ( 2 ), where L is the dianionic form of N ′-(2-hydroxy-5-methylbenzylidene)-2-methoxybenzohydrazide, have been synthesized and characterized by physicochemical methods and single-crystal X-ray diffraction. The V atom in each complex adopts octahedral coordination. Thermal stabilities and urease inhibitory activities of the complexes were studied. The percent inhibition of complexes 1 and 2 at the concentration of 100 μmol L −1 on Helicobacter pylori urease is 81.2 and 46.7 %, respectively. Complex 1 has an IC 50 value of 27.0 μmol L −1 . A molecular docking study of the complexes with the H. pylori urease was performed.