Role of multifunctional coactivator complex SAGA in regulation of eukaryotic gene expression

Eukaryotic gene expression is a multistep process of high complexity. Transcription is one of the cardinal and tightly regulated phases of gene expression. To provide accurate and precise work of the gene regulation apparatus, including a plethora of modifications of the chromatin structure and nucl...

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Published inMolecular biology (New York) Vol. 47; no. 6; pp. 796 - 802
Main Authors Gurskiy, D. Ya, Nabirochkina, E. N., Kopytova, D. V.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.11.2013
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Biosynthesis
Eukaryotes
Gene expression
Human Genetics
Life Sciences
Molecular biology
Reviews
acetylation
SCA7
mRNA export
Gcn5
deubiquitinating module (DUBm)
Sgf11
transcription
mRNP
ENY2/Sus1
SAGA complex
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Summary:Eukaryotic gene expression is a multistep process of high complexity. Transcription is one of the cardinal and tightly regulated phases of gene expression. To provide accurate and precise work of the gene regulation apparatus, including a plethora of modifications of the chromatin structure and nucleosome, dynamic turnover must take place. All transcription steps are under the control of large multiprotein coactivator complexes. In this review, we discuss the evolutionary conservative SAGA complex, which acetylates and deubiquitinates histones during transcription activation and, furthermore, is involved in subsequent stages of mRNP biogenesis and export.
Bibliography:ObjectType-Article-1
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ISSN:0026-8933
1608-3245
DOI:10.1134/S002689331306006X