Mast cells. Receptors, secretagogues, and signaling

Mast cells (MC) are a major cell type involved in a number of pathological processes, from local cutaneous reactions to systemic inflammatory responses, which if not controlled, could be life threatening. In these situations, MC are believed to be the initial effector cells. They express various rec...

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Published inClinical reviews in allergy & immunology Vol. 22; no. 2; pp. 119 - 148
Main Authors Sharma, Bhavya B, Apgar, John R, Liu, Fu-Tong
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.04.2002
Subjects
Animals
Humans
Immunologic Factors - physiology
Inflammation Mediators - physiology
Mast Cells - physiology
Receptors, IgE - physiology
Signal Transduction - physiology
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Summary:Mast cells (MC) are a major cell type involved in a number of pathological processes, from local cutaneous reactions to systemic inflammatory responses, which if not controlled, could be life threatening. In these situations, MC are believed to be the initial effector cells. They express various receptors, which, upon crosslinking or ligand binding, lead to the initiation of signaling events resulting in degranulation and/or synthesis and production of eicosanoids and cytokines. This is followed by events mediated by other cells types, including eosinophils, which culminate in the manifestation of the allergic disease.
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ISSN:1080-0549
1080-0549
1559-0267
DOI:10.1385/CRIAI:22:2:119