Accommodating planned exercise in type I diabetic patients on intensive treatment

• Published in: Diabetes care Vol. 8; no. 4; pp. 337 - 342
• Main Authors: Schiffrin, A, Parikh, S
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.07.1985
• Subjects: Adolescent; blood glucose; Blood Glucose - metabolism; diabetes; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; exercise; Female; Humans; hypoglycemia; insulin; Insulin - blood; Insulin Infusion Systems; Male; patient care; Physical Exertion; Time Factors
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.8.4.337

Glucose regulation was studied with/without postprandial exercise, and the effects of changes in insulin dosage were examined in 7 Type I diabetic adolescents treated with continuous subcutaneous insulin infusion (CSII) and 6 patients treated with multiple daily subcutaneous insulin injections (MSI). The effect of a 45-minute cycle exercise on glucose regulation was studied 2 hours after morning insulin and a breakfast meal. Exercise coupled with the usual insulin dose resulted in a significant decrease in glycemia in both CSII and MSI groups, which was corrected by oral dosing with about 25 g of glucose. Exercise coupled with 1/2 or 2/3 of the usual insulin dose resulted in a plasma glucose profile in both groups that was not significantly different from that observed on a day when no exercise was performed. Postprandial exercise without prior insulin dosing caused significant hyperglycemia in both CSII and MSI groups. Hence, an insulin dose reduction before postprandial exercise produced near-normal glycemic values and prevented hypoglycemia.(wz)