Epinephrine electrochemical sensor based on a carbon paste electrode modified with hydroquinone derivative and graphene oxide nano-sheets: Simultaneous determination of epinephrine, acetaminophen and dopamine

• Published in: Measurement : journal of the International Measurement Confederation Vol. 101; pp. 183 - 189
• Main Authors: Tezerjani, Marzieh Dehghan, Benvidi, Ali, Dehghani Firouzabadi, Afsaneh, Mazloum-Ardakani, Mohammad, Akbari, Ali
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.04.2017; Elsevier Science Ltd
• Subjects: Acetaminophen; Carbon; Chemical compounds; Chemical sensors; Dopamine; Electrocatalytic oxidation; Electrochemical analysis; Electrochemical sensor; Electrodes; Epinephrine; Graphene; Graphene oxide; Hydroquinone; Modified electrode; Nanoparticles; Oxidation; Prescription drugs; Sensors; Voltammetry; Epinephrine; Dopamine; Modified electrode; Acetaminophen; Electrocatalytic oxidation; Graphene oxide; Electrochemical sensor
• ISSN: 0263-2241; 1873-412X
• DOI: 10.1016/j.measurement.2017.01.029

[Display omitted] •Fabrication of an epinephrine sensor using CPE modified with GO and a modifier.•Simultaneous determination of epinephrine, acetaminophen and dopamine by EDDPT/GO/CPE.•The proposed sensor showed high sensitivity, repeatability and high stability.•The applicability of the proposed sensor in tablet and serum solutions samples. In this paper, an electrochemical sensor was constructed for determination of epinephrine based on carbon paste electrode (CPE) modified with graphene oxide (GO) and 2-(5-Ethyl-2,4-dihydroxyphenyl)-5,7-dimethyl-4H-pyrido[2,3-d][1,3]thiazine-4-one (EDDPT) as modifiers. The modified electrode was applied as an electrochemical sensor for oxidation of epinephrine (EP). Under the optimum conditions, the over potential of EP oxidation decreased about 279mV at the modified CPE more than a non-modified CPE. Electrochemical behavior of EP was investigated on the fabricated electrode by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods, and some kinetic parameters of EP were obtained, too. The linear range and the detection limit for EP were found to be 1.5–600.0μM and 0.65μM (based on 3s/m), respectively using the EDDPT/GO/CPE sensor and the differential pulse voltammetry (DPV) method. Also, the designed electrochemical sensor was applied to determine EP in the drug sample and simultaneous determination of epinephrine (EP), acetaminophen (AC) and dopamine (DA) in human serum solutions.